WYLDER NATION FOUNDATION

Conducts the ASMD Accelerate study in partnership with Picnic Health to advance real-world evidence and research on Acid Sphingomyelinase Deficiency (ASMD), including data collection and analysis to support therapeutic development.

Conducts biomarker discovery and drug screening research using model organisms and the ASM-KO mouse colony to identify therapeutic targets such as Sphingomyelin 16:0 and understand disease mechanisms in NPA and ASMD.

Operates a FAAH inhibitor program investigating FAAH inhibition as a therapeutic approach for neurovisceral acid sphingomyelinase deficiency, including preclinical and translational research.

The foundation advances research programs for Infantile Neurovisceral (NPA) and Chronic Neurovisceral (NPA/B) ASMD to develop treatment options, including operating a FAAH Inhibitor Program, a Gene Therapy program, maintaining an ASM-KO Mouse Colony, and conducting NPA Model Organism Development & Drug Screen research and Biomarker Discovery research. They also develop Real World Evidence (RWE) for ASMD and have launched the ASMD Accelerate study in partnership with Picnic Health.

Operates a gene therapy research program focused on developing treatments for Niemann-Pick disease, including work on adeno-associated viral vector serotype 9-based gene therapy for type A.

The foundation publishes and contributes to scientific publications on ASMD, including case reports on Niemann Pick Disease Type A, research on FAAH inhibition as a therapeutic approach, gene therapy, autopsy pathology, the role of sphingomyelin in neurodegeneration, lipid-induced lysosomal damage, and identifying therapeutic targets for neuronal death in ASMD.

Hosts the annual "Living Like A Warrior" gala event to raise awareness and support for the foundation, with documented events held from 2014 through 2023.

Maintains an ASM-KO mouse colony and conducts model organism development and drug screening research for NPA to support preclinical therapeutic development.

Conducts the ASMD Accelerate study in partnership with Picnic Health to advance real-world evidence and research on Acid Sphingomyelinase Deficiency (ASMD).

Conducts research to identify and validate biomarkers for ASMD to support diagnosis, monitoring, and treatment evaluation.

Operates a research program focused on FAAH inhibition as a potential therapeutic approach for neurovisceral acid sphingomyelinase deficiency, including preclinical and publication efforts.

The foundation provides a platform for individuals to create personalized fundraising pages to share their stories and raise funds for the foundation's research programs.

Operates a gene therapy research program, including development and testing of adeno-associated viral vector serotype 9-based therapies for Niemann-Pick disease type A.

The foundation recognizes individuals referred to as "Warriors With Wings" who have passed away, listing their names and dates of life.

The foundation hosts an annual fundraising event called the Living Like A Warrior Gala, which has been held since at least 2014.

Hosts the annual "Living Like A Warrior" gala event to support the foundation’s mission, with documented events from 2014 through 2023.

Provides an online contact form for individuals to submit inquiries or messages to the foundation.

Enables individuals to create personalized fundraising pages to share their stories and raise funds for the foundation’s research programs.

Develops real-world evidence for ASMD through data collection and research initiatives to inform clinical understanding and therapeutic development.

Advances research programs for Infantile Neurovisceral (NPA) and Chronic Neurovisceral (NPA/B) forms of ASMD to develop treatment options.

Advances research programs for Infantile and Chronic Neurovisceral Acid Sphingomyelinase Deficiency (Niemann-Pick Types A and B) to develop treatment options, including publication of clinicopathologic findings and therapeutic mechanisms.

Contributes to peer-reviewed scientific publications on Niemann-Pick disease and related lysosomal storage disorders, including pathology, mechanisms of neurodegeneration, and therapeutic targets.

Recognizes individuals referred to as "Warriors With Wings" who have passed away, honoring them by publishing their names and dates of life.

Recognizes individuals with Niemann-Pick disease who have passed away by honoring them as "Warriors With Wings" with their names and dates of life.